2-[[(E)-3-(4-PENTYLPHENYL)PROP-2-ENOYL]AMINO]BENZOIC ACID
N-(p-Amylcinnamoyl)anthranilic acid
CAS: 110683-10-8
Molecular Formula: C21H23NO3
2-[[(E)-3-(4-PENTYLPHENYL)PROP-2-ENOYL]AMINO]BENZOIC ACID - Names and Identifiers
2-[[(E)-3-(4-PENTYLPHENYL)PROP-2-ENOYL]AMINO]BENZOIC ACID - Physico-chemical Properties
| Molecular Formula | C21H23NO3 |
| Molar Mass | 337.41 |
| Density | 1.178±0.06 g/cm3(Predicted) |
| Melting Point | 172-174℃ |
| Boling Point | 563.1±50.0 °C(Predicted) |
| Solubility | DMSO: ≥20 mg/mL |
| Appearance | White to white-like powder |
| Color | White to Off-White |
| pKa | 3.49±0.36(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| In vitro study | N-(p-amylcinnamoyl) Anthranilic Acid (ACA; 20 μM) completely blocks ADPR-induced whole-cell currents and H 2 O 2 -induced Ca 2+ signals (IC 50 =1.7 μM) in HEK293cells transfected with human TRPM2. N-(p-amylcinnamoyl) Anthranilic Acid (ACA; 20 μM) also blocks currents through human TRPM8 and TRPC6 expressed in HEK293 cells. N-(p-amylcinnamoyl) Anthranilic Acid (ACA) modulates the activity of different TRP channels independent of PLA2 2 inhibition. |
2-[[(E)-3-(4-PENTYLPHENYL)PROP-2-ENOYL]AMINO]BENZOIC ACID - Risk and Safety
| Hazard Class | 9 |
2-[[(E)-3-(4-PENTYLPHENYL)PROP-2-ENOYL]AMINO]BENZOIC ACID - Reference Information
| biological activity | N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is an inhibitor of broad-spectrum phospholipase A2 (PLA2) and a blocker of TRP channel. N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is also an effective reversible inhibitor of calcium-activated chloride channels (calcium-activated chloride channels), which has the potential to be used in arrhythmia related research. |
| target | PLA 2 . TRP channel. Calcium-activated chloride channels. |
Last Update：2024-04-10 22:29:15
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View History
2-[[(E)-3-(4-PENTYLPHENYL)PROP-2-ENOYL]AMINO]BENZOIC ACID
H-PHE-ASP-OH
ETHYL 1-AMINOPYRROLE-2-CARBOXYLATE HCL
SODIUM D-ARABOASCORBATE MONOHYDRATE
EC 4.2.2.5
ETHYL-2-[[[[(4-CHLORO-6-METHOXY-2-PYRIMIDINYL)AMINO]CARBONYL]AMINO]-SULFONYL] BENZOATE
Pigment yellow 154 (C.I. 11781)
2-Bromopropionic acid tert-butyl ester
4-[(2-吡嗪基氨基)羰基]苯基硼酸
1-[(2-cyanophenoxy)acetyl]piperidine-4-carboxamide
H-PHE-ASP-OH
ETHYL 1-AMINOPYRROLE-2-CARBOXYLATE HCL
SODIUM D-ARABOASCORBATE MONOHYDRATE
EC 4.2.2.5
ETHYL-2-[[[[(4-CHLORO-6-METHOXY-2-PYRIMIDINYL)AMINO]CARBONYL]AMINO]-SULFONYL] BENZOATE
Pigment yellow 154 (C.I. 11781)
2-Bromopropionic acid tert-butyl ester
4-[(2-吡嗪基氨基)羰基]苯基硼酸
1-[(2-cyanophenoxy)acetyl]piperidine-4-carboxamide